Your body needs fatty acids to survive, though it is able to make all but two of them: linoleic acid (LA), in the omega-6 family, and alpha-linolenic acid (ALA) in the omega-3 family. These two fatty acids must be supplied from dietary sourced and are therefore considered essential fatty acids (EFAs). Omega-6 fatty acids are well-supplied via consumption of meat and vegetable oils. However, not all omega-6 fatty acids are of equal value. Arachidonic acid (AA), prostaglandin E2 (PGE2), thromboxane A2 and leukotriene B4 promote inflammation. In contrast, gamma-linolenic acid (GLA), found in evening primrose oil, borage oil and black currant oil, benefits healthy prostaglandin (PGE1) formation reduces inflammation. Health-conscious people have been swallowing many borage oil supplements to obtain GLA, the parent of the biologically active DGLA (dihomogamma linolenic acid). Life Extension adds 10 mg of sesame lignans to each softgel of Mega GLA borage oil. Sesame lignans increase beneficial DGLA and decreases inflammation. Numerous studies document GLA’s multiple health effects. Enhancing this supplement with sesame lignans leads to more efficiency in the body, which means more people can use it.