This Book Is A Revised Version Of The Phd Dissertation Written By The Author At The Department Of Business Informatics And Operations Management At Ghent University In Addresses Shortcomings In Business Process Management Concerning Loosely Framed Knowledge-intensive Processes, Which Are Characterized By Their Numerous Valid Process Variants And Their Reliance On Knowledge Workers To Apply Their Knowledge To Decide On A Suitable Process Variant That Fits The Context Of A Specific Process Execution. The Goal Was To Lay The Foundation For A Process-aware Business Process Management (it-)system To Support Such Processes. Several Proof-of-concept Implementations Have Been Made For The Core Components And Were Evaluated In The Domain Of The Healthcare.