Excedrin Migraine Pain Reliever 100 Caplets 2 Packs Excedrin Pain Reliever Migraine is specifically formulated to treat tough migraines. Each of the 100 caplets contains acetaminophen, aspirin and caffeine to provide maximum relief of migraines. Take two caplets a day for migraine headaches. These caplets will help relieve the pain that only a migraine can deliver. You should not take more than two Excedrin Pain Reliever Migraine caplets in 24 hours. Directions: Do not use more than directed. Keep box for reference. Adults, take 2 caplets with a glass of water; if symptoms persist or worsen, ask your doctor; do not take more than 2 caplets in 24 hours, unless directed by a doctor. Under 18 years of age, ask a doctor.