Louis starts his physiotherapy story in the 1970s. The first 3 sections describe who and what were influencing manual therapy in the 1980s. Louis questions the lack of pain discussion and understanding.Sections 19 discuss the dorsal horn memory biology placebo stress nociceptive pain mechanisms the sympathetic nervous system healing and adaptation.Section 10 describes how Louis developed The Mature Organism Model MOM which is now used worldwide to teach physiotherapists about inputoutput mechanisms and processing changes.Book one is an expansion of the first half of Louis 2 day lecture programme The Clinical Biology of Aches and Pains. A course Louis first taught in Adelaide in 1993 and continued to teach until he had to stop lecturing in 2007.