This book reviews the current knowledge of the globally circulating SARSCoV2 variants highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid19 pandemic. Furthermore the book explores how these variants do and may impact the efficacy of established neutralizing antibodybased nAb vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally the author discusses ways on how nAb Covid19 treatment derived immune escape of SARSCoV2 could be minimized in the future.